This dataset contains summary data visualizations and clinical data from the targeted sequencing of 10,000 clinical cases using the MSK-IMPACT assay. The clinical data includes mutation count, information about mutated genes, tumor mutational burden calculations, tissue site from which the sample was derived, tumor purity among other relevant data points. The data set also includes copy-number segment...

Summary from the GEO: "Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with unprecedented sensitivity. Flura-seq utilizes cytosine deaminase (CD) to convert...

Summary from the GEO: "Understanding the biology of rare cell populations in the context of their microenvironment requires an accurate analysis of the transcriptomes of these cells as expressed in situ. We developed fluorouracil-tagged RNA sequencing (Flura-seq) to characterize the transcriptomes of small cell subpopulations from a whole organ in model systems. The method utilizes cytosine deaminase...

This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...

This dataset contains summary data visualizations and clinical data from 67 samples from 67 patients as part an NCI-60 cell line project to compile NCI-60 cell line high-throughput and high-content data into CellMiner, a genomic and pharmacologic database created by the National Cancer Center Institute. The clinical data includes deidentified patient and sample IDs, mutation counts, detailed cancer...

TCGA Lung Squamous Cell Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 511 carcinomas from 511 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

This dataset contains the summary data visualizations and clinical data from targeted sequencing of 915 samples from 860 patients with metastatic lung adenocarcinoma. Clinical data includes: Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Diagnosis Age, Sex, Primary/Metastasis Sample Type, Chemotherapy, Clinical Trial, Driver Mutations, Durable Clinical Benefit, Gene Panel,...

This dataset contains the summary data visualizations and clinical data from targeted sequencing of 604 lung adenocarcinoma tumors from 604 patients via MSK-IMPACT. Clinical data includes: Mutation Count, Fraction Genome Altered, Sex, Age At Surgery, Clinical Nodal Status, CT Size, Diffusion lung capacity for carbon monoxide, FEV1, FGA Facets, Overall Survival Status, Pathologic Nodal Status Pathologic...

This dataset contains the summary data visualizations and clinical data from whole-exome sequencing of 75 tumor/normal NSCLC pairs treated with PD-1 plus CTLA-4 blockade from 75 patients. Clinical data includes: Mutation Count, Sex, Histology, Age (yrs), Best Overall Response, Durable Clinical Benefit, ECOG performance status, HLA_A1 allele, HLA_A2 alleles, HLA_B1 alleles, HLA_B2 alleles, HLA_C1 alleles,...

This dataset contains the summary data visualizations and clinical data from IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy from 240 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Durable Clinical Benefit, FGA, Gene Panel, IRB, Lines of treatment, Mutation Rate, Oncotree Code, PD-L1 Score (%), Smoker,...